（±）-N-（2-氟乙基）-2-甲基-5Z，8Z，11Z，14Z-二十碳四烯酰胺； 2-甲基-2'-氟AEA | 2-甲基-2'-氟阿南酰胺| O-689； （±）-2-甲基花生四烯酰基-2'-氟乙酰胺

背景资料

（±）-2-Methyl arachidonoyl-2’-fluoroethylamide （2-Methyl-2’-fluoro AEA） is an analog of anandamide （AEA） in which the alcohol of the ethanolamide group has been removed and replaced with a fluorine atom. This substitution confers considerably increased binding affinity for the CB1 receptor. It also confers additional selectivity， in that binding to CB2 is decreased relative to AEA. However， the in vivo activity of 2-fluoro AEA is enhanced much less than the binding affinity， because the analog remains a good substrate for FAAH and is rapidly hydrolyzed by this enzyme. 2-Methyl-2’-fluoro AEA is further modified by the addition of an .alpha.-methyl group at the C-2 position of arachidonic acid. This substitution confers enhanced metabolic stability. 2-Methyl-2’-fluoro AEA can fully substitute for .DELTA.9-THC in animal self-administration tests， whereas AEA and 2-fluoro AEA cannot.

保存条件

建议您在收到Cayman Chemical品牌的（±）-2-Methyl Arachidonoyl-2’-Fluoroethylamide （1 mg）产品后置于-20度保存，产品有效期为730天.

品牌介绍

Cayman Chemical向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒，其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.Cayman Chemical可提供用于检测的特色试剂盒，如：类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等；也提供多种高质量试剂，包括：类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为Cayman Chemical在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的Cayman Chemical产品以及客户订制化服务.

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