产品详情
Boc-PEG4-Val-Ala-PAB-PNP
Boc-PEG4-Val-Ala-PAB-PNP
Boc-PEG4-Val-Ala-PAB-PNP is an ADC linker featuring a Boc-protected amine, a hydrophilic PEG spacer, a Val-Ala dipeptide, a PAB group, and a PNP carbonate. The PNP carbonate is a leaving group that is highly activated towards attack from amines to form carbamates with the target molecule, while the Boc protecting group may be removed with acid to reveal a primary amine which can be used to couple with carboxylic acids. The Val-Ala dipeptide is cleaved by proteases to release a given drug payload via an elimination mechanism within the PAB group.
背景资料
Boc-PEG4-Val-Ala-PAB-PNP产品的分子式为C38H55N5O14，分子量为805.88715，
保存条件
Boc-PEG4-Val-Ala-PAB-PNP具体产品保存方法查看产品说明。
品牌介绍
BroadPharm是一个领先的以客户为中心的生物技术公司，总部位于圣地亚哥，BroadPharm致力于为全球客户提供高质量的PEG接头、Click Chemistry试剂、ADC接头、 PROTAC接头、药物递送脂质、核苷、亚磷酰胺和标记试剂。BroadPharm成立于2009年，生产超过2000种分散的，高纯度的聚乙二醇（PEG）试剂，目前这些PEG试剂广泛应用于生物偶联、抗体-药物偶联(ADC)治疗、药物递送和诊断领域。
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