产品详情
背景资料
TrkA is a member of the neurotrophic tyrosine kinase receptor family. It is a membrane-bound receptor that upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. TrkA is required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). TrkA leads to cell differentiations and may play a role in specifying sensory neuron subtypes. It has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. SUBUNIT: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. SUBCELLULAR LOCATION: TrkA is a heavily glycosylated transmembrane protein and contains 13 potential N-linked glycosylation sites. The TrkA-Fc chimera has N-linked and may have O-linked oligosaccharides.
应用类型
免疫原
宿主
人源细胞
反应性
保存条件
厂家推荐常温运输。建议保存冻干粉蛋白于2-8 ºC。溶解后建议分装保存于-20℃;短期保存可置于4℃。请避免反复冻融。
品牌介绍
Biosensis专注于神经科学领域的抗体和试剂的开发,特别是神经营养因子和神经营养因子受体。 近30年来,Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子,我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症(AD)、帕金森氏症(PD)和肌萎缩侧索硬化(ALS)疾病,以及自噬和代谢应激障碍,包括肥胖、代谢综合征的研究、神经免疫学和炎症。Biosensis的产品系列不仅包括持续增长的神经科学研究抗体系列,还包括200多种定量研究ELISAs试剂盒(1板或2板,自由选择),组织染色(退化神经元染色试剂盒、病理髓鞘染色试剂盒、淀粉样斑块染色试剂等)和细胞可视化试剂(染色)以及针对神经科学和细胞疾病研究的纯化的蛋白质。我们的抗体和试剂已被广泛应用于各种技术,包括蛋白质印迹,免疫组织化学,流式分析,共聚焦显微镜实时成像,生物抑制和细胞培养以及克隆。
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