DBCO-dPEG ® MAL-500 mg

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DBCO-dPEG®24-MAL, product number QBD-10594, is a long (90 atoms), single molecular weight, discrete polyethylene glycol (dPEG®) crosslinking reagent. The dibenzylcyclooctyne (DBCO) moiety permits strain promoted azide-alkyne cycloaddition (SPAAC), also known as "copper free click chemistry." The maleimidopropyl (MAL) functional group forms a thiol-ether linkage with sulfhydryl groups. The hydrophilic, non-immunogenic dPEG® spacer in DBCO-dPEG®24-MAL provides the benefits of PEG (increased water solubility, non-immunogenicity) without the analytical headaches of PEG dispersity. The copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) discovered by K. Barry Sharpless and coworkers is one of the best known click chemistry reactions, but its in vivo usability is limited by copper toxicity. Carolyn Bertozzi and coworkers developed SPAAC as a way to avoid copper’s toxic effects on living cells using a highly strained cyclooctyne. Developments since the initial publication show that reagents based on DBCO provide excellent, highly selective reactivity with azides, forming a triazole product. Maleimide groups are widely popular for their ability to react rapidly with sulfhydryl groups via a Michael addition to form thioether bonds. Vector Laboratories' dPEG® products clearly differ from traditional, polymeric polyethylene glycol (PEG). Traditional PEG is a disperse polymer product with a Poisson distribution of chain lengths and molecular weights. The intractable mixture of chain lengths and molecular weights in traditional PEG products creates significant analytical challenges. In contrast, Vector Laboratories' dPEG® products are single molecular weight compounds with discrete chain lengths. Using Vector Laboratories' products greatly simplifies analysis of dPEG®-conjugated compounds.
产品形式为浅黄色至浅琥珀色固体;在=25°C时可澄清

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品牌介绍

Click Chemistry Tools（CCT）公司位于美国亚利桑那州斯科茨代尔（Scottsdale,AZ）。自公司成立以来，一致致力于不断开发和扩展一系列连接产品。他们利用特别新的研究成果研发生产出新颖的交联和标记试剂。产品被广泛用于药物研发、癌症治疗以及各类诊断技术等。此外，CCT还可以提供个性化的定制产品，已满足不同用户的需求。目前CCT的产品线主要包括：Azides（Biotin-Azides）试剂、Bis-sulfone交联试剂、DBCO试剂、TCO试剂、Terminal Alkyne试剂、Tetrazine试剂、标记试剂盒以及分选用底物等。 Fluoroprobes公司位于美国亚利桑那州斯科茨代尔(Scottsdale, AZ)，自成立以来，一直致力于不断开发一系列的连接(linker)产品。利用特别新的研究成果研发生产出各类新颖的交联和标记试剂。其产品被广泛用于药物研发与筛选、疾病治疗方法和诊断技术等领域。此外，Fluoroprobes还可以根据客户的个性化需求提供各类定制连接产品。代表产品有Classic Fluorescent Dyes, AZDye, Cyanine Dyes, IR Dyes, MB dyes以及一些标记试剂盒等。 Quanta Biodesign公司位于美国中部的俄亥俄州，成立于1997年。也是专注于生产研发各类标记产品的品牌之一。其研发的产品与dPEG技术相结合，生产出他们独有的专利产品dPEG Building Blocks and Linkers，被广泛用于细胞治疗和分子诊断等研究领域。另外，还可为广大科研工作者提供多种化学修饰试剂以及传统Liner等。 目前上述三个品牌都已被被Vectorlabs收购并整合到Vectorlabs产品中

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