Amino-dPEG®氨基-叔丁基酯-1000 mg

背景资料

Amino-dPEG®36–t-butyl ester, product number QBD-10901, is a long (111 atoms, 132.7 Å), heterobifunctional, monodisperse polyethylene glycol (PEG) linker containing a single molecular weight, discrete length PEG (dPEG®) chain. One end of the dPEG® chain terminates with a carbonyl-reactive primary amine. The opposite end terminates with an amine-reactive, tert-butyl-ester-protected propionic acid. The t-butyl ester protecting group cleaves easily with trifluoroacetic acid (TFA), exposing a propionic acid moiety that forms amide bonds with primary amines upon activation. This compound is useful for supramolecular construction and building novel crosslinkers. Conjugates modified with QBD-10901 have improved water solubility and greater hydrodynamic volume. The amine end of the molecule reacts with activated carboxylic acid esters (for example, N-hydroxysuccinimidyl or tetrafluorophenyl esters) to form an amide bond. Also, carboxylic acids can couple to the amine end of Amino-dPEG®36-t-butyl ester using a carbodiimide such as EDC, with or without an acylating agent such as N-hydroxysuccinimide (NHS). After working up the reaction to remove unreacted components and isolate the intermediate, trifluoroacetic acid is used to remove the tert-butyl ester and expose the propionic acid end group. The exposed carboxylic acid can then react further. For example, activation as the NHS or TFP ester is possible. Also, the acid can be coupled directly to an amine as described above.
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品牌介绍

Click Chemistry Tools（CCT）公司位于美国亚利桑那州斯科茨代尔（Scottsdale,AZ）。自公司成立以来，一致致力于不断开发和扩展一系列连接产品。他们利用特别新的研究成果研发生产出新颖的交联和标记试剂。产品被广泛用于药物研发、癌症治疗以及各类诊断技术等。此外，CCT还可以提供个性化的定制产品，已满足不同用户的需求。目前CCT的产品线主要包括：Azides（Biotin-Azides）试剂、Bis-sulfone交联试剂、DBCO试剂、TCO试剂、Terminal Alkyne试剂、Tetrazine试剂、标记试剂盒以及分选用底物等。 Fluoroprobes公司位于美国亚利桑那州斯科茨代尔(Scottsdale, AZ)，自成立以来，一直致力于不断开发一系列的连接(linker)产品。利用特别新的研究成果研发生产出各类新颖的交联和标记试剂。其产品被广泛用于药物研发与筛选、疾病治疗方法和诊断技术等领域。此外，Fluoroprobes还可以根据客户的个性化需求提供各类定制连接产品。代表产品有Classic Fluorescent Dyes, AZDye, Cyanine Dyes, IR Dyes, MB dyes以及一些标记试剂盒等。 Quanta Biodesign公司位于美国中部的俄亥俄州，成立于1997年。也是专注于生产研发各类标记产品的品牌之一。其研发的产品与dPEG技术相结合，生产出他们独有的专利产品dPEG Building Blocks and Linkers，被广泛用于细胞治疗和分子诊断等研究领域。另外，还可为广大科研工作者提供多种化学修饰试剂以及传统Liner等。 目前上述三个品牌都已被被Vectorlabs收购并整合到Vectorlabs产品中

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