Amino-dPEG®-Tris(m-dPEG®)-100mg

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Amino-dPEG®12-Tris(m-dPEG®24)3, product number QBD-11474, is a carboxylate-reactive, methyl-terminated, four-arm monodispersed PEG product designed to modulate the pharmacokinetics (PK) and biodistribution (BD) of conjugates. It can also be used in surface passivation of organic, inorganic, and biomolecular surfaces. Tris forms the core of the molecule. Three equal-length (76 atoms) methyl-terminated long arms plus one shorter (40 atoms) maleimido-terminated arm extend from the tris core. The total length of the product from the reactive amine to each of the terminal methyl groups is 121 atoms (99.8 Å). The terminal primary amine reacts with carboxylic acids (carboxylates) and their active esters (e.g., NHS esters, TFP esters) to form stable amide bonds. The terminal amine also reacts with aldehydes to form a labile Schiff base that can be reduced to a stable secondary amine under mild conditions. The uncharged terminal methyl groups may alter the overall charge of the conjugate molecule. The amphiphilic dPEG® construct imparts hydrophilicity to conjugates, reduces or eliminates the conjugates’ antigenicity, and increases the hydrodynamic volume of conjugated molecules. With increased hydrodynamic volume, the renal clearance of conjugate molecules is reduced or eliminated. This product is designed for modifying biomolecules like antibodies and antibody fragments but can be used in any bioconjugate application where free carboxylates or their active esters are available for reaction. Potential product applications include reducing or eradicating renal clearance, extending in vivo circulating half-life, and suppressing immune responses to conjugates. Amino-dPEG®12-Tris(m-dPEG®24)3, product number QBD-11474, can passivate organic, inorganic, or biomoecular surfces to prevent non-specific, hydrophobic interactions.
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品牌介绍

Click Chemistry Tools（CCT）公司位于美国亚利桑那州斯科茨代尔（Scottsdale,AZ）。自公司成立以来，一致致力于不断开发和扩展一系列连接产品。他们利用特别新的研究成果研发生产出新颖的交联和标记试剂。产品被广泛用于药物研发、癌症治疗以及各类诊断技术等。此外，CCT还可以提供个性化的定制产品，已满足不同用户的需求。目前CCT的产品线主要包括：Azides（Biotin-Azides）试剂、Bis-sulfone交联试剂、DBCO试剂、TCO试剂、Terminal Alkyne试剂、Tetrazine试剂、标记试剂盒以及分选用底物等。 Fluoroprobes公司位于美国亚利桑那州斯科茨代尔(Scottsdale, AZ)，自成立以来，一直致力于不断开发一系列的连接(linker)产品。利用特别新的研究成果研发生产出各类新颖的交联和标记试剂。其产品被广泛用于药物研发与筛选、疾病治疗方法和诊断技术等领域。此外，Fluoroprobes还可以根据客户的个性化需求提供各类定制连接产品。代表产品有Classic Fluorescent Dyes, AZDye, Cyanine Dyes, IR Dyes, MB dyes以及一些标记试剂盒等。 Quanta Biodesign公司位于美国中部的俄亥俄州，成立于1997年。也是专注于生产研发各类标记产品的品牌之一。其研发的产品与dPEG技术相结合，生产出他们独有的专利产品dPEG Building Blocks and Linkers，被广泛用于细胞治疗和分子诊断等研究领域。另外，还可为广大科研工作者提供多种化学修饰试剂以及传统Liner等。 目前上述三个品牌都已被被Vectorlabs收购并整合到Vectorlabs产品中

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