NH2O®-Glu(OH)-NH-dPEG®--Glu(OH)-NH-m-dPEG®₂4.0-250 mg

背景资料

NH2-dPEG®4-Glu(OH)-NH-dPEG®4-Glu(OH)-m-dPEG®24, product number QBD-11624, is one of Vector Laboratories' unique, patented class of modular, designable payload delivery reagents called Sidewinder™. Sidewinder™ products are built on a discrete PEG (dPEG®) backbone for use in antibody-drug conjugates (ADCs) and related constructs. The payload (cytotoxin, dye, small molecule) loads onto the chain's sidearm. The distal end's methoxy-terminated dPEG®24 spacer protects payloads and modifies performance. The free primary amine of NH2-dPEG®4-Glu(OH)-NH-dPEG®4-Glu(OH)-m-dPEG®24, product number QBD-11624, reacts with carboxylic acids or their active esters (NHS ester, TFP ester) to form stable amide bonds. It is the attachment point for the Sidewinder™ to the biomolecule (e.g., mAb, Fab, Fab', targeting peptide, and so forth). The amine can be modified with a reactive group or conjugated directly to the carrier molecule. The backbone contains two carboxylic acid sidearms. After the primary amine is reacted, functionalized, or protected, the two sidearms can be conjugated to amine-containing payloads. The conjugation can be direct, using EDC or another suitable carbodiimide, or indirect, after first functionalizing the acid groups with N-hydroxysuccinimide (NHS ester) or 2,3,5,6-tetrafluorophenol (TFP ester) and then reacting the active esters with the amine-containing payloads. Sidewinder™ products are designed to facilitate the creation of stable, high-DAR ADCs. Published research has shown that putting a hydrophobic payload close to the antibody surface and protecting it with a SuperHydrophilic™ dPEG® construct is better by many measures of efficacy than putting the payload at the distal end of the linker. This molecule can also modify and optimize BD, cell trafficking and internalization, serum half-life, and immunogenicity. The dPEG® linkers and spacers in the Sidewinder™ construct are uniform, single molecular-weight PEGs with discrete chain lengths. In contrast, traditional, non-uniform polymer PEG linkers and spacers have a dispersed range of PEG chain lengths, each with a unique molecular weight. Unlike dispersed polymer PEGs, dPEG® products are high-purity compounds with reproducible purity profiles. Sidewinder™ molecules are also fully designable. NH2-dPEG®4-Glu(OH)-NH-dPEG®4-Glu(OH)-m-dPEG®24 can be modified to change the spacer lengths, add more sidearm attachment points, add different sidearm attachment points to carry payloads with other reactivities, change the amine attachment group to another reactive group, and many more customizations. Please inquire about your specific needs.
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品牌介绍

Click Chemistry Tools（CCT）公司位于美国亚利桑那州斯科茨代尔（Scottsdale,AZ）。自公司成立以来，一致致力于不断开发和扩展一系列连接产品。他们利用特别新的研究成果研发生产出新颖的交联和标记试剂。产品被广泛用于药物研发、癌症治疗以及各类诊断技术等。此外，CCT还可以提供个性化的定制产品，已满足不同用户的需求。目前CCT的产品线主要包括：Azides（Biotin-Azides）试剂、Bis-sulfone交联试剂、DBCO试剂、TCO试剂、Terminal Alkyne试剂、Tetrazine试剂、标记试剂盒以及分选用底物等。 Fluoroprobes公司位于美国亚利桑那州斯科茨代尔(Scottsdale, AZ)，自成立以来，一直致力于不断开发一系列的连接(linker)产品。利用特别新的研究成果研发生产出各类新颖的交联和标记试剂。其产品被广泛用于药物研发与筛选、疾病治疗方法和诊断技术等领域。此外，Fluoroprobes还可以根据客户的个性化需求提供各类定制连接产品。代表产品有Classic Fluorescent Dyes, AZDye, Cyanine Dyes, IR Dyes, MB dyes以及一些标记试剂盒等。 Quanta Biodesign公司位于美国中部的俄亥俄州，成立于1997年。也是专注于生产研发各类标记产品的品牌之一。其研发的产品与dPEG技术相结合，生产出他们独有的专利产品dPEG Building Blocks and Linkers，被广泛用于细胞治疗和分子诊断等研究领域。另外，还可为广大科研工作者提供多种化学修饰试剂以及传统Liner等。 目前上述三个品牌都已被被Vectorlabs收购并整合到Vectorlabs产品中

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