DSP 7238 | Equa | Galvus | LAF 237; 1- [2-[（3-羟基三环[3.3.1.13,7]癸-1-基）氨基]乙酰基] -2S-吡咯烷甲腈 CAS:138-52-3

背景资料

Glyptins are a class of oral antihyperglycemic agents that inhibit dipeptidyl peptidase 4 (DPP-4), which can act as a serine exopeptidase.{24375} In addition to having use in type 2 diabetes, gliptins have positive cardiovascular and anti-inflammtatory effects.{17148,24374,24375} Vildagliptin is an inhibitor of DPP-4 (IC50 = 3.5-34 nM).{24373,24372} It also inhibits DPP-8 and DPP-9 (Ki = 810 and 95 nM, respectively) but not DPP-2 or the related fibroblast activation protein α.{24377} Through its effects on DPP-4, it blocks the degradation of several circulating peptides, including incretins (stimulators of insulin secretion) like glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1.{24376,24378} Vildagliptin reduces fasting and postprandial glucose levels and decreases inflammatory and oxidative stress in diverse animal models of disease.{24374,24375}

保存条件

建议您在收到Cayman Chemical品牌的Vildagliptin (100 mg)产品后置于-20度保存，产品有效期为730天.

品牌介绍

Cayman Chemical向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒，其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.Cayman Chemical可提供用于检测的特色试剂盒，如：类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等；也提供多种高质量试剂，包括：类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为Cayman Chemical在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的Cayman Chemical产品以及客户订制化服务.

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