Raf激酶抑制剂V；N- [3-[（5-氯-1H-吡咯并[2,3-b]吡啶-3-基）羰基] -2,4-二氟苯基] -1-丙烷磺酰胺 CAS:1428118-38-0

背景资料

The Raf kinases activate cellular pathways that lead to cell proliferation and can contribute to certain types of cancer.{19941,24815} Mutations in the kinase B-raf (BRAF) are involved in a wide range of cancers.{18549,22622} In particular, the mutation BRAFV600E occurs in melanomas and thyroid cancer but is poorly targeted by many inhibitors of wild type BRAF.{24813,24814} PLX4720 is an orally-available, highly selective inhibitor of BRAFV600E (IC50 = 13 nM).{24814} It is less effective against wild type BRAF (IC50 = 160 nM) as well as several other kinases.{24814} PLX4720 induces cell cycle arrest and apoptosis in cells and xenografts expressing the mutant of BRAF.{24813,24814,24812}

保存条件

建议您在收到Cayman Chemical品牌的PLX4720 (5 mg)产品后置于-20度保存，产品有效期为730天.

品牌介绍

Cayman Chemical向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒，其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.Cayman Chemical可提供用于检测的特色试剂盒，如：类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等；也提供多种高质量试剂，包括：类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为Cayman Chemical在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的Cayman Chemical产品以及客户订制化服务.

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