产品详情
SA 333 | SQ 14,225; 1-[((2S)-3-巯基-2-甲基-1-氧丙基] -L-脯氨酸 CAS:144171-61-9
SA 333|SQ 14,225; 1-[(2S)-3-mercapto-2-methyl-1-oxopropyl]-L-proline
An ACE inhibitor (IC50 = 6.3 nM) that does not exhibit a domain preference for binding either the C- or N-terminal active sites of the somatic form of ACE; reversibly inhibits LTA4 hydrolase, inhibiting LTB4 synthesis (IC50 = 14 μM)
背景资料
Angiotensin-converting enzyme (ACE) removes the C-terminal dipeptide from angiotensin I to form angiotensin II, a powerful vasoconstrictor. ACE is a key regulator of the renin-angiotensin system and an important drug target for the treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing renal and retinal complications in diabetes.{10615} As the first nonpeptidic ACE inhibitor to be developed (IC50 = 6.3 nM), captopril was discovered based on bradykinin-potentiating peptides isolated from the venom of B. Jararaca, a pit viper native to Brazil.{25199,25197} It does not exhibit a domain preference for binding either the C- or N-terminal active sites of the somatic form of ACE, which may account for some of captopril’s negative side effects.{25198} Captopril is also a competitive and reversible inhibitor of leukotriene (LTA4) hydrolase, which results in the disruption of LTB4 synthesis at an IC50 value of 14 μM.{25196}
保存条件
建议您在收到Cayman Chemical品牌的Captopril (10 g)产品后置于-20度保存,产品有效期为730天.
品牌介绍
Cayman Chemical向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒,其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.Cayman Chemical可提供用于检测的特色试剂盒,如:类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等;也提供多种高质量试剂,包括:类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为Cayman Chemical在中国的区域总代理,艾美捷科技有限公司将为中国客户提供最全面的Cayman Chemical产品以及客户订制化服务.
FAQ
文献