产品详情
Itabastatin | Itavastatin | NK 104; (3R,5S,6E)-7- [2-环丙基-4-(4-氟苯基)-3-喹啉基] -3,5-二羟基-6 -庚酸,单钙盐 CAS:1449747-00-5
Itabastatin|Itavastatin|NK 104; (3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid, monocalcium salt
A potent inhibitor of HMG-CoA reductase (Ki = 1.7 nM); lowers both total cholesterol and LDL cholesterol in animals and humans
背景资料
The statins are a family of compounds that inhibit 3-hydroxy-3-methyl glutaryl coenzyme A (HMG-CoA) reductase, a pivotal enzyme in cholesterol biosynthesis.{20936} Pitavastatin is a potent inhibitor of HMG-CoA reductase (Ki = 1.7 nM).{25250} It lowers both total cholesterol and low density lipoprotein cholesterol in animals and humans.{25248} Metabolism of pitavastatin by the cytochrome P450 system is minimal, reducing the risk of drug-drug interactions.{25248} Moreover, pitavastatin causes atherosclerosis regression in humans with subclinical carotid atherosclerosis and improves cardiac function and survival in a rat model of hypertensive heart failure.{25249,25247}
保存条件
建议您在收到Cayman Chemical品牌的Pitavastatin (calcium salt) (10 mg)产品后置于-20度保存,产品有效期为730天.
品牌介绍
Cayman Chemical向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒,其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.Cayman Chemical可提供用于检测的特色试剂盒,如:类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等;也提供多种高质量试剂,包括:类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为Cayman Chemical在中国的区域总代理,艾美捷科技有限公司将为中国客户提供最全面的Cayman Chemical产品以及客户订制化服务.
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