Silmitasertib; 5-[（3-氯苯基）氨基]-苯并[c] -2,6-萘啶-8-羧酸 CAS:16220-07-8

背景资料

CX-4945 is a potent, orally bioavailable inhibitor of casein kinase 2 (CK2; Ki = 0.38 nM) that competes with ATP by filling the small ATP binding site on the catalytic CK2α subunit, conferring selectivity.{27517,27516,27518} It inhibits proliferation in a panel of cancer cell lines that overexpress CK2 and prevents tumor growth of breast and pancreatic cancer cell xenografts in mice.{27518} CX-4945 blocks survival and induces apoptosis in cancer stem cells and is effective against glioblastomas and acute myeloid leukemia cells.{27520,27519} CX-4945 also inhibits Cdc2-like kinases (Clk; IC50s = 82.3, 3.8, and 90 nM for Clk1, Clk2, and Clk3, respectively), interfering with alternative splicing.{26173}

保存条件

建议您在收到Cayman Chemical品牌的CX-4945​ (10 mg)产品后置于-20度保存，产品有效期为730天.

品牌介绍

Cayman Chemical向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒，其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.Cayman Chemical可提供用于检测的特色试剂盒，如：类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等；也提供多种高质量试剂，包括：类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为Cayman Chemical在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的Cayman Chemical产品以及客户订制化服务.

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