产品详情
DBF | NSC 645658;2- [3-氧代-6-(苯基甲氧基)-3H-噻吨-9-基]-苯甲酸苯基甲基酯 CAS:1624-62-0
DBF|NSC 645658; 2-[3-oxo-6-(phenylmethoxy)-3H-xanthen-9-yl]-benzoic acid phenylmethyl ester
A fluorogenic probe that acts as a substrate for specific cytochrome P450 (CYP) isoforms, including CYP3A4, CYP2C8, CYP2C9, CYP2C19, and aromatase (CYP19); used to detect changes in CYP catalytic activity caused by drugs or disease
背景资料
Dibenzylfluorescein is a fluorogenic probe that acts as a substrate for specific cytochrome P450 (CYP) isoforms, including CYP3A4, CYP2C8, CYP2C9, CYP2C19, and aromatase (CYP19).{27561,27560,27562} Dibenzylfluorescein is dealkylated by these CYP isoforms to produce fluorescein benzyl ether, which is further hydrolyzed to fluorescein by the addition of base (typically 2 M NaOH).{27562} Dibenzylfluorescein is typically used near its apparent Km value of 0.87-1.9 µM.{27561,27560,27562} The fluorescence of fluorescein is evaluated using excitation/emission wavelengths of 485/538 nm. Dibenzylfluorescein is used to detect changes in CYP catalytic activity caused by drugs or disease.{27561,27563}
保存条件
建议您在收到Cayman Chemical品牌的Dibenzylfluorescein (5 mg)产品后置于-20度保存,产品有效期为730天.
品牌介绍
Cayman Chemical向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒,其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.Cayman Chemical可提供用于检测的特色试剂盒,如:类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等;也提供多种高质量试剂,包括:类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为Cayman Chemical在中国的区域总代理,艾美捷科技有限公司将为中国客户提供最全面的Cayman Chemical产品以及客户订制化服务.
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