产品详情
WWL123 CAS:1628260-79-6
WWL123
A brain-penetrant, selective inhibitor of ABHD6 (IC50 = 0.43 µM) that has been used to decrease seizure incidence in a genetic mouse model of juvenile Huntington’s disease as well as in chemically-induced epilepsy models
背景资料
The serine hydrolase known as α/β-hydrolase domain-containing protein 6 (ABHD6) hydrolyzes 2-arachidonoyl glycerol (Item No. 62160) to regulate its availability at cannabinoid receptors.{15253} WWL123 is a brain-penetrant inhibitor of ABHD6 (IC50 = 0.43 µM) that demonstrates >10-fold selectivity for ABHD6 compared to a panel of ~35 other serine hydrolases.{27126} Inhibition of ABHD6 by WWL123 has been used to decrease seizure incidence in a genetic mouse model of juvenile Huntington’s disease as well as in chemically-induced epilepsy models.{27125}
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品牌介绍
Cayman Chemical向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒,其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.Cayman Chemical可提供用于检测的特色试剂盒,如:类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等;也提供多种高质量试剂,包括:类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为Cayman Chemical在中国的区域总代理,艾美捷科技有限公司将为中国客户提供最全面的Cayman Chemical产品以及客户订制化服务.
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