P32 / 98（半富马酸盐） CAS:163042-96-4

背景资料

The glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) are responsible for a majority of nutrient-stimulated insulin secretion. After being released into the circulation, GIP and GLP-1 are inactivated by the circulating enzyme dipeptidyl peptidase IV (DPP IV). DPP IV inhibitors have emerged as a new class of experimental antidiabetic agents. P32/98 is a competitive transition-state substrate analog inhibitor of DPP IV (Ki = 126 nM).{24373} At 20 mg/kg/day, it has been used to improve glucose tolerance, insulin sensitivity, and β-cell glucose responsiveness in diabetic rat models.{27894}

保存条件

建议您在收到Cayman Chemical品牌的P32/98 (hemifumarate) (1 mg)产品后置于-20℃保存.

品牌介绍

Cayman Chemical向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒，其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.Cayman Chemical可提供用于检测的特色试剂盒，如：类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等；也提供多种高质量试剂，包括：类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为Cayman Chemical在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的Cayman Chemical产品以及客户订制化服务.

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