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VER-155008 CAS:1698055-85-4

VER-155008

An inhibitor of Hsp70 (IC50 = 0.5 µM) that is selective over Hsp90; binds the NBDs of Hsc70 (Ki = 10 µM) and Grp78 (KD = 80 nM); inhibits the proliferation of human breast and colon cancer cell lines, inducing apoptosis or caspase-independent cell death

货号:17257-5品牌:Cayman Chemical 规格:5mg价格:询价元 说明书:点击查看 COA下载:点击查看

背景资料


VER-155008 is an adenosine-derived inhibitor of heat shock protein 70 (Hsp70; IC50 = 0.5 µM) that is selective over Hsp90.{28942} It targets the nucleotide-binding domain (NBD) of Hsp70 and similarly binds the NBDs of Hsp70 cognates Hsc70 (Ki = 10 µM) and glucose-regulated protein 78 (Grp78; KD = 80 nM).{28941,28939} VER-155008 inhibits the proliferation of human breast and colon cancer cell lines, inducing apoptosis or caspase-independent cell death.{28940} It induces the proteasome-dependent degradation of Hsp90 client proteins and potentiates the apoptotic activity of Hsp90 inhibitors.{28942,28940} VER-15508 also triggers paraptosis in anaplastic thyroid carcinoma cells.{28938}

保存条件


建议您在收到Cayman Chemical品牌的VER-155008 (5 mg)产品后置于-20℃保存.

品牌介绍


Cayman Chemical向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒,其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.Cayman Chemical可提供用于检测的特色试剂盒,如:类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等;也提供多种高质量试剂,包括:类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为Cayman Chemical在中国的区域总代理,艾美捷科技有限公司将为中国客户提供最全面的Cayman Chemical产品以及客户订制化服务.

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