产品详情
N-（3-吡啶基）-1-（4-氯苯甲酰基）-5-甲氧基-2-甲基-1H-吲哚-3-乙酰胺； N-3PyIA； N-（3-吡啶基）-吲哚美辛酰胺
N-（3-pyridyl）-1-（4-chlorobenzoyl）-5-methoxy-2-methyl-1H-indole-3-acetamide； N-3PyIA； N-（3-pyridyl）-Indomethacin amide
N-3PyIA is one of several aromatic amides of indomethacin reported to be potent and selective reversible inhibitors of COX-2.{8243} N-3PyIA selectively inhibits human recombinant COX-2 with an IC50 of 52 nM. It is about 1，300 times less potent as an inhibitor of ovine COX-1.{8243} However， N-3PyIA does not distinguish between ovine COX-1 and -2. The IC50 values for ovine COX-1 and -2 are 75 and 50 uM， respectively.{8513}
背景资料
N-（3-pyridyl）-indomethacin amide （N-3PyIA） is one of several aromatic amides of indomethacin reported to be potent and selective reversible inhibitors of COX-2. N-3PyIA selectively inhibits human recombinant COX-2 with an IC50 of 0.052 uM. It is about 1，300 times less potent as an inhibitor of ovine recombinant COX-1. However， N-3PyIA is not selective as an inhibitor of ovine seminal vesicular COX-1 and ovine placental COX-2. The IC50 values for ovine COX-1 and -2 are 75 and 50 uM， respectively.
保存条件
建议您在收到Cayman Chemical品牌的N-（3-pyridyl）-Indomethacin amide （5 mg）产品后置于-20度保存，产品有效期为365天.
品牌介绍
Cayman Chemical向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒，其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.Cayman Chemical可提供用于检测的特色试剂盒，如：类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等；也提供多种高质量试剂，包括：类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为Cayman Chemical在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的Cayman Chemical产品以及客户订制化服务.
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