产品详情
5-[[4- [2-（5-乙基-2-吡啶基）乙氧基]苯基]甲基] -2，4-噻唑烷二酮；吡格列酮
5-[[4-[2-（5-ethyl-2-pyridinyl）ethoxy]phenyl]methyl]-2，4-thiazolidinedione； Pioglitazone
Thiazolidinediones （TZDs） are a group of structurally related PPAR.gamma. agonists with anti-diabetic actions in vivo.{7575，8930} Rosiglitazone （BRL49653） is a prototypical TZD and has served as a reference compound for this class of PPAR.gamma. ligands.{8461} Pioglitazone is a closely related TZD which also selectively activates PPAR.gamma.-1. Pioglitazone is about one tenth as potent as rosiglitazone， with an EC50 of about 500-600 nM for both human and mouse PPAR.gamma..{10857，10670} In a transactivation assay using COS-1 cells transfected with full length human PPAR.alpha. and RXR.alpha.， pioglitazone and rosiglitazone exhibit low level activation of PPAR.alpha. at 1 uM and 5.4- and 4.2-fold activation， respectively， at a concentration of 10 uM.{10857}
背景资料
Thiazolidinediones （TZDs） are a group of structurally related PPAR.gamma. agonists with anti-diabetic actions in vivo. Rosiglitazone （BRL49653） is a prototypical TZD and has served as a reference compound for this class of PPAR.gamma. ligands. Pioglitazone is a closely related TZD which also selectively activates PPAR.gamma.-1. Pioglitazone is about one tenth as potent as rosiglitazone， with an EC50 of about 500-600 nM for both human and mouse PPAR.gamma.. In a transactivation assay using COS-1 cells transfected with full length human PPAR.alpha. and RXR.alpha.， pioglitazone and rosiglitazone exhibit low level activation of PPAR.alpha. at 1 uM and 5.4- and 4.2-fold activation， respectively， at a concentration of 10 uM.
保存条件
建议您在收到Cayman Chemical品牌的Pioglitazone （50 mg）产品后置于-20度保存，产品有效期为365天.
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Cayman Chemical向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒，其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.Cayman Chemical可提供用于检测的特色试剂盒，如：类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等；也提供多种高质量试剂，包括：类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为Cayman Chemical在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的Cayman Chemical产品以及客户订制化服务.
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