产品详情
2,3,10,11,12,13-六氢-10R-甲氧基-9S-甲基-11R-甲基氨基-9S,13R-环氧-1H,9H-二吲哚[1,2,3-gh; 3',2 ',1'-lm]吡咯并[3,4-j] [1,7]苯并重氮-1-酮; Stsp;星形孢菌素
2,3,10,11,12,13-hexahydro-10R-methoxy-9S-methyl-11R-methylamino-9S,13R-epoxy-1H,9H-diindolo[1,2,3-gh; 3’,2’,1’-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one; Stsp; Staurosporine
Stsp is potent inhibitor of PKC from rat brain, exhibiting an IC50 value of 2.7 nM.{9054} It inhibits rat recombinant PKC-.alpha. approximately 100- and 1,000-fold better than PKC-.delta. and PKC-.zeta., respectively.{9107} However, Stsp is non-selective in that it also inhibits the activity of a variety of other protein kinases, not only PKC isoforms.{9106} The biological effects of Stsp include cytotoxicity, relaxation of smooth muscle, and regulation of eNOS gene expression.{9106,8207}
背景资料
Staurosporine (Stsp) is potent inhibitor of protein kinase C (PKC) from rat brain, exhibiting an IC50 value of 2.7 nM. It inhibits rat recombinant PKC-.alpha. approximately 100- and 1,000-fold better than PKC-.delta. and PKC-.zeta., respectively. However, Stsp is non-selective in that it also inhibits the activity of a variety of other protein kinases, not only PKC isoforms. The biological effects of Stsp include cytotoxicity, relaxation of smooth muscle, and regulation of eNOS gene expression.
保存条件
建议您在收到Cayman Chemical品牌的Staurosporine (500 ug)产品后置于-20度保存,产品有效期为365天.
品牌介绍
Cayman Chemical向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒,其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.Cayman Chemical可提供用于检测的特色试剂盒,如:类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等;也提供多种高质量试剂,包括:类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为Cayman Chemical在中国的区域总代理,艾美捷科技有限公司将为中国客户提供最全面的Cayman Chemical产品以及客户订制化服务.
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