N-[（7S）-5，6，7，9-tetrahydro-1，2，3，10-四甲氧基-9-氧代苯并[a]庚二烯-7-基]-乙酰胺；秋水仙碱

背景资料

Colchicine inhibits microtubule polymerization （IC50 = 3.2 uM） by binding to tubulin， which disrupts spindle formation during mitosis. Since increased rate of mitosis is associated with cancer cell proliferation， blocking microtubule function with colchicine has been used as an approach to anti-cancer therapy. For instance， colchicine blocks the growth of MCF-7 human breast carcinoma cells with an IC50 value of 13 nM. Its mitosis-inhibiting function is also utilized to perform karyotypes in genetic studies. Colchicine produces anti-inflammatory effects by inhibiting neutrophil motility and activity （5 umol/kg in a mouse model of gouty arthritis） and inhibits the deposition of uric acid， a key aspect in the treatment of gout.

保存条件

建议您在收到Cayman Chemical品牌的Colchicine （250 mg）产品后置于-20度保存，产品有效期为730天.

品牌介绍

Cayman Chemical向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒，其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.Cayman Chemical可提供用于检测的特色试剂盒，如：类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等；也提供多种高质量试剂，包括：类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为Cayman Chemical在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的Cayman Chemical产品以及客户订制化服务.

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